Exploring the Link Between Gut Microbiota and Insomnia Diagnosis Based on the Concept of "If the Stomach is Unharmonious, the Sleep will be Restless"

Abstract

This template explains and demonstrates how to prepare your camera-ready paper In the dual context of global financial digital transformation and intensified competition Objective: To investigate the association between gut microbiota and the diagnosis and treatment of insomnia.  Methods: First, a two-sample Mendelian randomization analysis was conducted between gut microbiota data and insomnia, using the inverse variance weighted method as the primary outcome measure. Subsequently, genetic variants associated with insomnia were annotated to identify corresponding genes.  Results: Our analysis identified six pathogenic bacterial taxa associated with insomnia, and found that SUCLG2 and TM9SF2 may serve as key regulatory genes.  Conclusion: Our study provides insights for the development of personalized treatment strategies for insomnia and offers preliminary candidate targets for future drug development.