Frontiers in Healthcare Technology
type: channel
description: Frontiers in Healthcare Technology is a peer-reviewed journal that focuses on cutting-edge research and advancements in the field of healthcare technology.
publisher: INTERNATIONAL STUDY COUNSELOR
language: en
publication name: Frontiers in Healthcare Technology
issn: 3079-6601
items: Exploring the Link Between Gut Microbiota and Insomnia Diagnosis Based on the Concept of "If the Stomach is Unharmonious, the Sleep will be Restless"
items: Research Progress on Small Intestinal Bacterial Overgrowth in Liver Cirrhosis: From Diagnosis via Methane and Hydrogen Breath Tests to Clinical Management
items: Regulatory Mechanisms of Inflammatory Signaling Pathways in Atherosclerosis by Traditional Chinese Medicine
items: Mechanistic Study of Erchen Decoction Combined with Taohong Siwu Decoction in Ameliorating Atherosclerosis in ApoE⁻/⁻ Mice by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway
items: Explainable ICU Mortality Prediction with Temporal Attention and Clinically Constrained Feature Attributions
items: Pathology Whole-Slide Classification with Hierarchical Tokenization and Multi-Instance Learning
items: Metabolomics-Based Discovery of Biomarkers for Oral Squamous Cell Carcinoma and Their Clinical Utility
items: Progress in Early Diagnosis of Oral Squamous Cell Carcinoma: From Cytology to AI-Based Imaging Analysis
items: Evaluation of Depth-Sensing Accuracy for AR Surgical Guidance in Dynamic Operating Room Environments
items: Research on Influencing Factors of Information Addiction in the Elderly Based on the COM-B Model
items: Efficient Knowledge-Synthesized Feature Learning for Industrial Food Safety Inspection
items: Research Progress and Treatment Strategy of Asthma
items: Progress on Adipose Tissue Dysfunction in the Pathogenesis of Obesity-Related Hypertension
items: Therapeutic Factors in Nature-Based Therapies: Uncovering the Healing Benefits of Integrating Nature into Psychotherapy
items: Wearable Health Devices in Chronic Disease Management: Opportunities, Challenges, and Future Directions
items: Blockchain Applications in Healthcare: Ensuring Data Security and Patient Privacy
items: "Internet+" Mobile Application for Blood Pressure Management in Hypertensive Patients: A Meta-Analysis
items: Comparison of Ancient and Modern Therapies: A Case Study on Xiao Chai Hu Decoction in the Treatment of Digestive System Diseases
items: Navigating Ethical Challenges in Genetic Editing: Implications for Clinical Practice
items: Exploring the Efficacy of Telemedicine in Rural Healthcare Delivery: A Systematic Review
items: The Development of Targeted Therapies for Autoimmune Diseases: Current Status and Future Prospects
items: Advances in Precision Medicine: Tailoring Treatments to Individual Genomes.
items: The Impact of Digital Health Records on Patient Outcomes and Healthcare Efficiency
items: The Future of Vaccine Development: Leveraging mRNA Technology for Infectious Diseases
items: Innovations in Personalized Oncology: Integrating Genomic Data into Cancer Treatment
items: Analyzing the Effectiveness of Public Health Campaigns in Preventing Non-Communicable Diseases
items: Evaluating the Effectiveness of Mobile Health Apps in Chronic Disease Management
items: Exploring the Role of Big Data in Predicting and Preventing Epidemics
items: Integrative Approaches to Pain Management: Combining Conventional and Alternative Therapies
items: Advancements in Minimally Invasive Surgical Techniques: Benefits and Risks

Exploring the Link Between Gut Microbiota and Insomnia Diagnosis Based on the Concept of "If the Stomach is Unharmonious, the Sleep will be Restless"
type: item
description: This template explains and demonstrates how to prepare your camera-ready paper In the dual context of global financial digital transformation and intensified competition Objective: To investigate the association between gut microbiota and the diagnosis and treatment of insomnia. Methods: First, a two-sample Mendelian randomization analysis was conducted between gut microbiota data and insomnia, using the inverse variance weighted method as the primary outcome measure. Subsequently, genetic variants associated with insomnia were annotated to identify corresponding genes. Results: Our analysis identified six pathogenic bacterial taxa associated with insomnia, and found that SUCLG2 and TM9SF2 may serve as key regulatory genes. Conclusion: Our study provides insights for the development of personalized treatment strategies for insomnia and offers preliminary candidate targets for future drug development.
subject: Articles
  topic: section
subject: Gut Microbiota
  topic: keywords
subject: Insomnia
  topic: keywords
subject: Traditional Chinese Medicine
  topic: keywords
creator: Zhe Wang
rights: Copyright (c) 2026 Zhe Wang (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-28
publication date: 2026-01-28
starting page: 26
ending page: 30
doi: 10.71465/fht597

Research Progress on Small Intestinal Bacterial Overgrowth in Liver Cirrhosis: From Diagnosis via Methane and Hydrogen Breath Tests to Clinical Management
type: item
description: In this paper, the author has tried to present a systematic review of the current research developments on the topic of small intestinal bacterial overgrowth (SIBO) in liver cirrhosis, focusing on its pathophysiology, non - invasive diagnosis, and its impact on patient outcomes. It discusses the mechanisms by which the changes in the intestinal environment consequent to cirrhosis promote abnormal bacteria growth in the small intestine by a synthesis of recent basic and clinical evidence. In addition, it discusses the mechanisms where the increased intestinal permeability, inflammation, and bacterial translocation worsen the progression of diseases and complications. It also evaluates the applicability, limitations, and optimization plans of the hydrogen breath test of this category of patients. The existing evidence indicates that SIBO is strongly common among the patients with cirrhosis and is closely associated with the level of disease and its complications manifested as hepatic encephalopathy, infections, and nutritional disorders. Meanwhile, hydrogen breath test is one of the main screening tools that are suitable to be utilized on cirrhotic patients. To sum up, SIBO has an important role in the course of cirrhosis and emergence of related issues, and it has probable potential in the early identification of high - risk patients and treatment recommendations.
subject: Articles
  topic: section
subject: Breath hydrogen test
  topic: keywords
subject: Cirrhosis
  topic: keywords
subject: Small intestinal bacterial overgrowth
  topic: keywords
subject: Diagnosis
  topic: keywords
creator: Nong Ziqin
creator: Li Hongxuan
creator: Huang Hongna
creator: Huang Jingjing
rights: Copyright (c) 2026 Nong Ziqin, Li Hongxuan, Huang Hongna, Huang Jingjing (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-18
publication date: 2026-01-18
starting page: 15
ending page: 25
doi: 10.71465/fht587

Regulatory Mechanisms of Inflammatory Signaling Pathways in Atherosclerosis by Traditional Chinese Medicine
type: item
description: Atherosclerosis is the main pathological basis of cardiovascular disease. According to the Report on Cardiovascular Health and Diseases in China 2023, there are about 290 million patients in China, and related deaths account for more than 40% of total mortality. Inflammation plays a central role in the onset and progression of atherosclerosis by impairing endothelial function, promoting foam cell formation, and destabilizing plaques, thus forming a persistent “inflammation–injury” cycle. Current Western medical treatments, such as lipid-lowering drugs, antiplatelet therapy, and vascular interventions, remain limited by adverse drug reactions and restenosis. Guided by the holistic perspective and pattern-based treatment of Traditional Chinese Medicine (TCM), therapeutic strategies emphasize the regulation of yin–yang balance and pathological factors such as phlegm, stasis, and toxins, showing multi-component and multi-target advantages. Recent studies have demonstrated that single compounds, herb pairs, and formulae can modulate inflammatory pathways including NF-κB, TLRs, MAPK, and JAK/STAT, thereby suppressing pro-inflammatory cytokines, improving endothelial function, regulating lipid metabolism, and slowing plaque progression. This article reviews research advances over the past five years on TCM interventions in atherosclerosis, aiming to provide theoretical support for mechanistic studies and clinical applications.
subject: Articles
  topic: section
subject: Atherosclerosis
  topic: keywords
subject: Inflammation; Signaling Pathways
  topic: keywords
subject: Traditional Chinese Medicine
  topic: keywords
subject: NF-κB
  topic: keywords
creator: Zhonghao Yuan
creator: Mengqian Liu
creator: Hanwen Zheng
creator: Binghao Pan
creator: Ting Guo
creator: Yan Chen
rights: Copyright (c) 2026 Zhonghao Yuan, Mengqian Liu, Hanwen Zheng, Binghao Pan, Ting Guo, Yan Chen (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-18
publication date: 2026-01-18
starting page: 7
ending page: 14
doi: 10.71465/fht584

Mechanistic Study of Erchen Decoction Combined with Taohong Siwu Decoction in Ameliorating Atherosclerosis in ApoE⁻/⁻ Mice by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway
type: item
description: Objective： This study aimed to evaluate whether Erchen Decoction combined with Taohong Siwu Decoction exerts anti-atherosclerotic effects by modulating the p53/SLC7A11 pathway and ferroptosis. Methods： An atherosclerosis model was established by feeding ApoE⁻/⁻ mice a high-fat diet. The mice were randomly divided into five groups: model group, low-, medium-, and high-dose TCM groups, and a simvastatin group, with a normal-diet group serving as control. Following 4 weeks of treatment, aortic plaque formation was examined, serum levels of SOD, MDA, and GSH were assessed, and protein and mRNA expression in aortic tissues were detected via immunohistochemistry and RT-PCR. Results： Compared with the model group, the combined administration of Erchen Decoction and Taohong Siwu Decoction markedly reduced aortic plaque area, elevated serum SOD and GSH activities, and lowered MDA levels (P < 0.05 or P < 0.01). Additionally, it downregulated mRNA expression of p53, PTGS2, and NOX1 and COX2 protein expression in aortic tissue, while upregulating mRNA expression of SLC7A11, GPX4, and FTH1, as well as FTH1 protein expression. Conclusion: Erchen Decoction combined with Taohong Siwu Decoction may exert anti-atherosclerotic effects by inhibiting p53 expression and activating the SLC7A11/GPX4 axis, thereby alleviating oxidative damage and suppressing ferroptosis.
subject: Articles
  topic: section
subject: Erchen Decoction
  topic: keywords
subject: Taohong Siwu Decoction
  topic: keywords
subject: Atherosclerosis
  topic: keywords
subject: Ferroptosis
  topic: keywords
subject: , p53/SLC7A11 Pathway
  topic: keywords
creator: Zhonghao Yuan
creator: Shiyu Lin
creator: Binghao Pan
creator: Mengqian Liu
creator: Ting Guo
creator: Hanwen Zheng
creator: Yan Chen
rights: Copyright (c) 2026 Zhonghao Yuan, Shiyu Lin, Binghao Pan, Mengqian Liu, Ting Guo, Hanwen Zheng, Yan Chen (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-18
publication date: 2026-01-18
starting page: 1
ending page: 6
doi: 10.71465/fht581

Explainable ICU Mortality Prediction with Temporal Attention and Clinically Constrained Feature Attributions
type: item
description: The rapid digitization of healthcare infrastructure has resulted in the proliferation of Electronic Health Records (EHRs), providing a fertile ground for data-driven clinical decision support systems. Among the most critical applications is the prediction of mortality in Intensive Care Units (ICUs), where early identification of deteriorating patients can significantly influence survival outcomes. While Deep Learning (DL) models, particularly Recurrent Neural Networks (RNNs) and Transformers, have demonstrated superior predictive performance compared to traditional scoring systems, their deployment is frequently hindered by a lack of interpretability. This paper introduces a novel architecture that integrates Temporal Attention mechanisms with Clinically Constrained Feature Attributions to predict ICU mortality. Unlike standard interpretability methods that provide post-hoc explanations, our approach incorporates domain knowledge directly into the training process via a regularization term that penalizes physiologically implausible feature associations. We evaluate our model on the MIMIC-III dataset, demonstrating that it achieves state-of-the-art predictive performance while generating explanations that align with clinical consensus. The results indicate that enforcing clinical constraints does not degrade accuracy; rather, it improves the model's robustness and trustworthiness, facilitating safer integration into clinical workflows.
subject: Articles
  topic: section
subject: ICU Mortality Prediction
  topic: keywords
subject: Deep Learning,
  topic: keywords
subject: Temporal Attention
  topic: keywords
subject: Explainable AI,
  topic: keywords
subject: Clinical Decision Support.
  topic: keywords
creator: Bo Zhu
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 133
ending page: 140
doi: 10.71465/fht554

Pathology Whole-Slide Classification with Hierarchical Tokenization and Multi-Instance Learning
type: item
description: The digitization of histopathology has ushered in a new era of computational diagnostics, wherein Whole-Slide Images (WSIs) serve as the primary data modality for automated disease classification and grading. However, the gigapixel resolution of WSIs presents a significant computational bottleneck, necessitating the division of slides into tens of thousands of patches. This granularity introduces a "bag-of-instances" problem typically addressed via Multiple Instance Learning (MIL). While conventional MIL approaches aggregate patch-level features, they often fail to capture long-range spatial dependencies and tissue macro-architecture due to the prohibitive sequence lengths when applied to standard Transformer models. This paper introduces a novel framework: Hierarchical Tokenization with Multi-Instance Learning (HT-MIL). Our approach employs a dynamic, multi-scale tokenization strategy that groups spatially coherent and semantically similar patches into super-tokens before processing them through a hierarchical attention mechanism. This reduces the effective sequence length while preserving local cellular details and global tissue context. We evaluate HT-MIL on two large-scale public benchmark datasets. The results demonstrate that our method achieves state-of-the-art classification performance while significantly reducing computational overhead compared to non-hierarchical vision transformers.
subject: Articles
  topic: section
subject: Computational Pathology
  topic: keywords
subject: Whole-Slide Imaging
  topic: keywords
subject: Multi-Instance Learning, Vision Transformers
  topic: keywords
subject: Hierarchical Tokenization.
  topic: keywords
creator: Minglei Xie
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 141
ending page: 148
doi: 10.71465/fht555

Metabolomics-Based Discovery of Biomarkers for Oral Squamous Cell Carcinoma and Their Clinical Utility
type: item
description: The most common pathological type of the oral malignancies is oral squamous cell carcinoma (OSCC). Most patients visit the doctor when they notice signs like pain, ulceration, or dysphagia, and as such, patients have not been identified as soon as possible and recurrence and lymph node metastasis have formed the basis of survival. Metabolomics, which concentrates on small-molecule metabolites, has the potential to generate comprehensive >single cell-type phenotypic readout of tumor cell metabolic reorganization, host immune reactions, nutrition, and microecological disturbances on biofluids and tissues, thereby providing translatable leads in noninvasive screening, risk stratification, and longitudinal follow-up herein OSCC. As a strategy, this article consists of synthizing available evidence as well as systematically re-presenting resources of published findings, providing the discovery pathway of OSCC metabolic biomarkers based on sample types (plasma/serum/saliva/tissue), analytical platforms (NMR and mass spectrometry) and statistical modeling (multivariate discrimination and targeted validation). Quantitative findings directly presented in three published papers are compiled into re-usable graphical evidence: subgroup effects on ROC performance (AUC, sensitivity, specificity) of a plasma multivariate model based on NMR; monotonic fluctuations of key serum metabolites between stages I and IV (Lu et al., 2025); AUC ranking of various biomarkers of selected metabolites in tumor tissue (Zhou et al., 2020). Taken together, the evidence indicates that evidence of OSCC metabolic biomarkers can be extrapolated beyond “case control discrimination to staging aggressiveness stratification in spite of more stringent cohort matching coupled with confounding controls, cross-platform reproducibility, more rigorous targeted quantification workflows and multicenter prospective validation models.
subject: Articles
  topic: section
subject: Oral squamous cell carcinoma
  topic: keywords
subject: Metabolomics
  topic: keywords
subject: Liquid biopsy
  topic: keywords
subject: Staging
  topic: keywords
subject: ROC
  topic: keywords
subject: Lipid metabolism
  topic: keywords
creator: Zhou Tianyi
creator: Xu Jiayi
creator: Zhou Wenjing
creator: Wang Mengge
creator: Li Ying
rights: Copyright (c) 2025 Zhou Tianyi, Xu Jiayi, Zhou Wenjing, Wang Mengge, Li Ying (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-23
publication date: 2025-12-23
starting page: 124
ending page: 132
doi: 10.71465/fht491

Progress in Early Diagnosis of Oral Squamous Cell Carcinoma: From Cytology to AI-Based Imaging Analysis
type: item
description: Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and its five-year survival rate is highly dependent on the timing of diagnosis. In recent years, advances in cytology, optical imaging technologies, and artificial intelligence (AI) based image analysis have enriched the available strategies for early detection of OSCC. This review summarizes traditional diagnostic approaches, including oral brush cytology, liquid-based cytology, tissue biopsy, and immunohistochemistry. It further highlights recent developments in optical techniques such as narrow-band imaging and autofluorescence-based methods, and provides an overview of emerging deep learning driven automated recognition technologies. Current evidence suggests that future OSCC early-diagnosis systems will evolve toward multimodal, intelligent, and non-invasive frameworks, offering greater potential for improving clinical outcomes.
subject: Articles
  topic: section
subject: Oral squamous cell carcinoma (OSCC)
  topic: keywords
subject: Early diagnosis
  topic: keywords
subject: Cytology
  topic: keywords
subject: Optical imaging
  topic: keywords
subject: Narrow-band imaging
  topic: keywords
subject: Autofluorescence
  topic: keywords
subject: Artificial intelligence (AI)
  topic: keywords
subject: Deep learning
  topic: keywords
creator: Jiayi Xu
creator: Wenjing Zhou
creator: Liping Gui
creator: Hengrui Deng
creator: Tianyi Zhou
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-07
publication date: 2025-12-07
starting page: 117
ending page: 124
doi: 10.71465/fht462

Evaluation of Depth-Sensing Accuracy for AR Surgical Guidance in Dynamic Operating Room Environments
type: item
description: Operating rooms pose challenges for depth sensing due to variable illumination and instrument occlusion. We benchmarked Kinect v2, RealSense D455, and HoloLens 2 across 100 trials simulating surgical conditions. Metrics included mean depth error, temporal stability, and robustness to glare. Results showed Kinect v2 error at 2.7 mm, HoloLens 2 at 1.9 mm, and RealSense at 1. 1 mm. Stability under surgeon motion was highest with RealSense (94% valid frames). Recommendations include hybrid calibration workflows and adaptive denoising for clinical adoption.
subject: Articles
  topic: section
subject: depth-sensing evaluation
  topic: keywords
subject: AR surgical navigation
  topic: keywords
subject: device benchmarking
  topic: keywords
subject: operating room robustness
  topic: keywords
creator: Adrian K. Wong
creator: Victor T. Ho
creator: Samuel C. Lee
creator: Mei L. Chan
creator: Carmen Y. Lau
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-30
publication date: 2025-11-30
starting page: 111
ending page: 116
doi: 10.71465/fht453

Research on Influencing Factors of Information Addiction in the Elderly Based on the COM-B Model
type: item
description: [Purpose/Significance] Studying the influencing factors of information addiction in the elderly is conducive to promoting the elderly to use various types of information more scientifically and healthily, and helping them better adapt to the digital transformation of society. [Method/Process] Based on the COM-B model, this study collected 350 valid questionnaires, focusing on three dimensions: Capability (information literacy, cognitive function), Opportunity (technological accessibility, social support level), and Motivation (positive psychological capital, fear of missing out). Empirical research was conducted using structural equation modeling. [Result/Conclusion] The results show that information literacy, cognitive function, social support level, and positive psychological capital have a significant negative impact on the elderly's tendency toward information addiction, while technological accessibility and fear of missing out have a significant positive impact. The mediating effect test reveals that positive psychological capital and fear of missing out play significant mediating roles in multiple pathways.
subject: Articles
  topic: section
subject: COM-B Model
  topic: keywords
subject: Information Addiction
  topic: keywords
subject: Elderly
  topic: keywords
subject: Influencing Factors
  topic: keywords
subject: Structural Equation Modeling
  topic: keywords
creator: Tingting Li
rights: Copyright (c) 2025 Tingting Li (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-18
publication date: 2025-10-18
starting page: 91
ending page: 110
doi: 10.71465/fht386

Efficient Knowledge-Synthesized Feature Learning for Industrial Food Safety Inspection
type: item
description: The rapid advancement of machine learning and computer vision technologies has revolutionized industrial food safety inspection systems. However, traditional approaches often rely on isolated feature extraction methods that fail to capture the complex interdependencies between visual, spectroscopic, and contextual information critical for comprehensive food safety assessment. This paper proposes a novel Knowledge-Synthesized Feature Learning (KSFL) framework that integrates multi-modal sensory data through a hierarchical knowledge synthesis architecture. The proposed methodology combines Convolutional Neural Networks (CNNs) with domain-specific knowledge graphs to enhance feature representation and improve detection accuracy for various food safety hazards including contamination, spoilage, and foreign object detection. Our experimental evaluation on a comprehensive dataset of 15,000 food samples across five industrial processing facilities demonstrates significant improvements in detection accuracy (94.7%) compared to traditional computer vision approaches (87.2%) and conventional machine learning methods (82.1%). The system achieves real-time processing capabilities with an average inference time of 23.4 milliseconds per image, making it suitable for high-throughput industrial applications. Furthermore, the knowledge synthesis approach demonstrates superior generalization across different food categories and environmental conditions, reducing false positive rates by 31% and improving overall system reliability. This research contributes to the advancement of intelligent food safety inspection systems by providing a robust framework for knowledge-guided feature learning that bridges the gap between automated inspection technology and domain expertise.
subject: Articles
  topic: section
subject: Knowledge synthesis
  topic: keywords
subject: feature learning
  topic: keywords
subject: food safety inspection
  topic: keywords
subject: machine learning
  topic: keywords
subject: computer vision
  topic: keywords
subject: industrial automation
  topic: keywords
creator: Eva Smit
creator: Tom de Boer
creator: Lisa Meijer
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 77
ending page: 90
doi: 10.71465/fht373

Research Progress and Treatment Strategy of Asthma
type: item
description: Asthma, as a common respiratory disease, is primarily caused by airway inflammation and airway wall remodeling, which are also its key pathological features. Its development is closely related to genetic, environmental, and immune system abnormalities. Asthma presents in a variety of phenotypes, including allergic, non-allergic, adult-onset, and persistent airflow limitation types, and these phenotypes may vary with age, gender, and environmental factors. In terms of treatment, inhaled corticosteroids, long-acting β2 receptor agonists, and biologics have become standard therapeutic approaches. In recent years, biologics have provided new treatment hope for T2-high asthma, but further research is still needed for T2-low asthma treatment. Therefore, this review summarizes the epidemiological characteristics, pathophysiological mechanisms, disease classification criteria, and current treatment and prevention strategies of asthma, aiming to provide insights for future exploration of the disease's underlying mechanisms and innovative treatment methods, to alleviate the disease burden and improve patients' health outcomes.
subject: Articles
  topic: section
subject: Asthma
  topic: keywords
subject: Biopreparations
  topic: keywords
subject: Targeted Therapy
  topic: keywords
subject: Mechanisms of pathology
  topic: keywords
creator: Danni Hui
rights: Copyright (c) 2025 Danni Hui (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-27
publication date: 2025-09-27
starting page: 69
ending page: 76
doi: 10.71465/fht363

Progress on Adipose Tissue Dysfunction in the Pathogenesis of Obesity-Related Hypertension
type: item
description: Obesity has become one of the most prominent public health challenges of the new century, and its close association with hypertension constitutes a major global disease burden. Once considered a passive energy reservoir, adipose tissue is now redefined as a metabolically active endocrine and paracrine organ. In obesity, abnormal expansion and dysfunction of adipose tissue drive the elevation of blood pressure through multiple complex and intertwined mechanisms. This review aims to explore in depth the central role of adipose tissue dysfunction in the pathogenesis of obesity-related hypertension, with a particular focus on the latest advances regarding key pathways such as physical compression, imbalance in adipokine secretion, local activation of the renin-angiotensin-aldosterone system (RAAS), chronic low-grade inflammation, and insulin resistance. Understanding these mechanisms is crucial for developing novel strategies for the prevention and treatment of obesity-related hypertension.
subject: Articles
  topic: section
subject: Obesity-related hypertension
  topic: keywords
subject: Adipose tissue dysfunction
  topic: keywords
subject: Pathogenesis
  topic: keywords
creator: Shiyu Lin
creator: Ke Liu
creator: Zhonghao Yuan
creator: Hanwen Zheng
creator: Ziyi Gu
creator: Yiwen Fan
creator: Bingbing Ning
creator: Hui Zheng
creator: Zimiao Lin
rights: Copyright (c) 2025 Shiyu Lin, Ke Liu, Zhonghao Yuan, Hanwen Zheng, Ziyi Gu, Yiwen Fan, Bingbing Ning, Hui Zheng, Zimiao Lin (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-13
publication date: 2025-09-13
starting page: 64
ending page: 68
doi: 10.71465/fht335

Therapeutic Factors in Nature-Based Therapies: Uncovering the Healing Benefits of Integrating Nature into Psychotherapy
type: item
description: While the integration of nature into therapeutic practice, often termed Nature-Based Therapies (NBTs) or ecotherapy, is gaining empirical validation for improving mental health outcomes, the specific mechanisms underlying these benefits remain insufficiently consolidated. Traditional therapeutic factors, such as the therapeutic alliance and catharsis, are well-understood in clinical settings, yet it is unclear how these factors are expressed, altered, or augmented by the introduction of the natural environment as an active component of the treatment. This research investigates the unique and synergistic therapeutic factors inherent in NBTs. The primary objective is to develop a synthesized framework that identifies and analyzes the specific mechanisms through which the natural environment contributes to therapeutic change, differentiating passive environmental exposure from the active integration of nature into psychotherapeutic processes. This paper utilizes a simulated qualitative descriptive methodology, synthesizing data derived from foundational literature and a simulated cohort of NBT practitioners and clients to explore these underlying factors. The analysis culminates in the identification of three primary meta-factors: (1) The Environment as a Restorative Container, facilitating regulation and cognitive restoration; (2) Nature as an Active Co-Therapist, providing metaphorical resonance and processing pathways; and (3) The Ecological Reframing of the Therapeutic Dyad, which de-pathologizes distress and enhances the therapeutic alliance through embodied experience. The findings suggest that the efficacy of NBTs relies not merely on the restorative setting, but on the environment's active role as a catalyst for psychodynamic, cognitive, and relational processes. This framework offers significant implications for clinical training, therapeutic standardization, and the optimization of NBT interventions.
subject: Articles
  topic: section
subject: Nature-Based Therapies
  topic: keywords
subject: Ecotherapy
  topic: keywords
subject: Therapeutic Factors
  topic: keywords
subject: Psychotherapy Integration
  topic: keywords
subject: Attention Restoration Theory (ART)
  topic: keywords
subject: Biophilia Hypothesis
  topic: keywords
subject: Therapeutic Mechanisms
  topic: keywords
subject: Environmental Psychology
  topic: keywords
creator: Rui Chen
rights: Copyright (c) 2025 Rui Chen (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-12
publication date: 2025-09-12
starting page: 51
ending page: 63
doi: 10.71465/fht332

Wearable Health Devices in Chronic Disease Management: Opportunities, Challenges, and Future Directions
type: item
description: Wearable health devices have emerged as powerful tools in chronic disease management, offering real-time health monitoring, early detection of complications, and improved patient engagement. These devices, including smartwatches, fitness trackers, and specialized medical sensors, are increasingly integrated into healthcare systems to manage conditions such as diabetes, cardiovascular diseases, and respiratory disorders. Despite their potential, challenges remain, including data privacy concerns, device accuracy, interoperability issues, and user adherence. This paper explores the current opportunities, challenges, and future directions for wearable health devices in chronic disease management, highlighting the importance of integrating these technologies with robust data security frameworks and personalized healthcare approaches.
subject: Articles
  topic: section
subject: wearable health devices
  topic: keywords
subject: chronic disease management
  topic: keywords
subject: telehealth
  topic: keywords
subject: patient engagement
  topic: keywords
subject: data privacy
  topic: keywords
subject: remote monitoring
  topic: keywords
creator: Dr. Emily Thompson
rights: Copyright (c) 2025 Dr. Emily Thompson (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 27
ending page: 33
doi: 10.71465/fht298

Blockchain Applications in Healthcare: Ensuring Data Security and Patient Privacy
type: item
description: Blockchain technology has emerged as a transformative solution for the healthcare sector, addressing critical challenges in data security, patient privacy, and interoperability. By leveraging decentralized and immutable ledgers, blockchain ensures that medical records remain secure, tamper-proof, and accessible only to authorized parties. This paper explores the applications of blockchain in healthcare, highlighting its role in safeguarding patient data, preventing fraud, reducing operational costs, and enabling efficient data sharing. Furthermore, it discusses current limitations, regulatory challenges, and future prospects for large-scale adoption.
subject: Articles
  topic: section
subject: blockchain
  topic: keywords
subject: healthcare technology
  topic: keywords
subject: data security
  topic: keywords
subject: patient privacy
  topic: keywords
subject: interoperability
  topic: keywords
subject: digital health
  topic: keywords
creator: Dr. Sophia Martinez
rights: Copyright (c) 2025 Dr. Sophia Martinez (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 18
ending page: 26
doi: 10.71465/fht295

"Internet+" Mobile Application for Blood Pressure Management in Hypertensive Patients: A Meta-Analysis
type: item
description: Objective: To investigate the effectiveness of mobile applications in blood pressure control. Methods: Randomized controlled trials (RCTs) examining the effects of "Internet+" mobile application-based nursing interventions on blood pressure management in hypertensive patients were retrieved from five databases: China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and Embase. The search spanned up to April 7, 2024. Following literature screening, abstract review, and risk-of-bias assessment, a meta-analysis was conducted using RevMan 5.4.1 software. Results: Seven studies were included, with the following outcome measures analyzed: ① Systolic blood pressure (SBP): MD = 2.60, 98% CI (1.47, 3.73), P < 0.05; ② Diastolic blood pressure (DBP): MD = 1.63, 98% CI (0.52, 2.75), P < 0.05; ③ Medication adherence: SMD = 0.36, 98% CI (0.21, 0.51), P < 0.05. Conclusion: "Internet+" mobile healthcare nursing interventions significantly improve blood pressure management outcomes in hypertensive patients, enhance medication adherence, and promote better blood pressure control.
subject: Articles
  topic: section
subject: Hypertension
  topic: keywords
subject: Internet
  topic: keywords
subject: Meta-analysis.
  topic: keywords
creator: Xuan Fan1,
creator: Jinzhen Jin1
rights: Copyright (c) 2025 Dr. Sophia Martinez (Author) https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 1
ending page: 8
doi: 10.71465/fht293

Comparison of Ancient and Modern Therapies: A Case Study on Xiao Chai Hu Decoction in the Treatment of Digestive System Diseases
type: item
description: Xiao Chai Hu Decoction originates from Shang Han Lun, and its formulation principle of "harmonizing cold and heat" holds significant value in the treatment of digestive system diseases. Ancient physicians used "fullness in the chest and ribs" and "bitter taste in the mouth and dry throat" as core diagnostic criteria (Shang Han Ming Li Lun), while modern research has confirmed that this formula can regulate the 5-HT transporter (SERT mRNA expression increased by 2.1 times) and improve gastrointestinal motility (Wang et al., 2023). There is currently a gap in systematic research on the differences in the application of this formula across time, especially in terms of cross-era comparisons of the pathological mechanisms. This article integrates classical medical case records with clinical trial data, combined with molecular biology techniques, to reveal the evolutionary patterns of the diagnostic and therapeutic paradigm of Xiao Chai Hu Decoction.
subject: Articles
  topic: section
subject: Xiao Chai Hu Decoction
  topic: keywords
subject: Cold and Heat Harmonization
  topic: keywords
subject: Gastrointestinal Diseases
  topic: keywords
subject: 5-HT Transporter
  topic: keywords
creator: Jiaying Wang
creator: Huiyu Ruan
creator: Zhonghao Yuan
creator: Shiyu Lin
creator: Liu Yang
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-05-19
publication date: 2025-05-19
starting page: 9
ending page: 17
doi: 10.71465/fht235

Navigating Ethical Challenges in Genetic Editing: Implications for Clinical Practice
type: item
description: Genetic editing technologies, such as CRISPR-Cas9, have revolutionized the field of molecular biology and medicine by offering unprecedented precision in modifying genetic material. However, these advancements come with significant ethical challenges that impact clinical practice. This article explores the ethical considerations associated with genetic editing, including the potential for unintended genetic consequences, issues of consent, and the broader societal implications. Through a review of current literature and case studies, this paper aims to provide a comprehensive overview of the ethical dilemmas faced by clinicians, researchers, and policymakers in the context of genetic editing. The implications for clinical practice are discussed, highlighting the need for robust ethical guidelines and regulations to ensure responsible use of these technologies.
subject: Articles
  topic: section
subject: Genetic Editing
  topic: keywords
subject: CRISPR-Cas9
  topic: keywords
subject: Ethical Challenges
  topic: keywords
subject: Clinical Practice
  topic: keywords
subject: Genetic Modifications
  topic: keywords
subject: Consent
  topic: keywords
subject: Societal Implications
  topic: keywords
creator: Dr. Ayesha Khan
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 34
ending page: 41
doi: 10.71465/fht126

Exploring the Efficacy of Telemedicine in Rural Healthcare Delivery: A Systematic Review
type: item
description: Telemedicine has emerged as a transformative solution to address healthcare access challenges, particularly in rural areas where traditional medical services are often limited. This systematic review aims to evaluate the efficacy of telemedicine in rural healthcare delivery by analyzing recent studies and trials. The review synthesizes evidence on the effectiveness of telemedicine interventions in improving health outcomes, patient satisfaction, and cost efficiency. Key findings indicate that telemedicine can significantly enhance access to care, reduce travel burdens, and improve chronic disease management in rural settings. However, challenges such as technological barriers and the need for infrastructure development are also noted. This review provides insights into the benefits and limitations of telemedicine, offering recommendations for optimizing its implementation in rural healthcare systems.
subject: Articles
  topic: section
subject: Telemedicine
  topic: keywords
subject: Rural Healthcare
  topic: keywords
subject: Efficacy
  topic: keywords
subject: Systematic Review
  topic: keywords
subject: Healthcare Delivery
  topic: keywords
creator: Dr. Sarah Qureshi
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 114
ending page: 122
doi: 10.71465/fht125

The Development of Targeted Therapies for Autoimmune Diseases: Current Status and Future Prospects
type: item
description: Autoimmune diseases, characterized by the immune system attacking the body's own tissues, present significant therapeutic challenges. Traditional treatments often involve broad immunosuppressive therapies, which can lead to adverse effects and suboptimal outcomes. Recent advancements in targeted therapies aim to address these challenges by specifically targeting the underlying mechanisms of autoimmune diseases. This article reviews the current state of targeted therapies for autoimmune diseases, including monoclonal antibodies, small molecules, and biologics. It discusses their mechanisms of action, clinical efficacy, and safety profiles. Additionally, the article explores future directions in the development of targeted therapies, highlighting emerging technologies and novel targets. The review concludes with an assessment of the potential for personalized medicine approaches to enhance treatment outcomes for patients with autoimmune disorders.
subject: Articles
  topic: section
subject: Autoimmune Diseases
  topic: keywords
subject: Targeted Therapies
  topic: keywords
subject: Monoclonal Antibodies
  topic: keywords
subject: Biologics
  topic: keywords
subject: Personalized Medicine
  topic: keywords
creator: Dr. Imran Ali
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 108
ending page: 113
doi: 10.71465/fht124

Advances in Precision Medicine: Tailoring Treatments to Individual Genomes.
type: item
description: Precision medicine represents a transformative approach in healthcare, focusing on customizing treatment plans based on an individual's genetic profile. Recent advancements in genomic technologies have enabled a more detailed understanding of the genetic basis of diseases, leading to more effective and personalized treatment strategies. This article reviews the latest developments in precision medicine, highlighting the integration of genomic data into clinical practice and its impact on treatment outcomes. It explores key areas such as the identification of genetic variants, the role of bioinformatics, and the challenges and future directions of implementing precision medicine in diverse populations. Through a comprehensive review of current literature and case studies, this article aims to provide insights into how precision medicine is reshaping modern healthcare and improving patient care.
subject: Articles
  topic: section
subject: Precision Medicine
  topic: keywords
subject: Genomics
  topic: keywords
subject: Personalized Treatment
  topic: keywords
subject: Genetic Variants
  topic: keywords
subject: Disease Management
  topic: keywords
creator: Dr. Usman Raza
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 42
ending page: 50
doi: 10.71465/fht123

The Impact of Digital Health Records on Patient Outcomes and Healthcare Efficiency
type: item
description: Digital Health Records (DHRs) have transformed the healthcare landscape by enhancing the accessibility, accuracy, and efficiency of patient information management. This paper evaluates the impact of DHRs on patient outcomes and healthcare efficiency. By conducting a comprehensive review of recent literature, the study highlights both positive and negative aspects of DHR implementation. Key findings indicate that DHRs improve patient outcomes through better care coordination, reduced errors, and increased patient engagement. However, challenges such as data security, system interoperability, and user training must be addressed to fully realize their potential. This paper provides recommendations for optimizing DHR systems to enhance their benefits for patients and healthcare providers.
subject: Articles
  topic: section
subject: Digital Health Records
  topic: keywords
subject: Patient Outcomes
  topic: keywords
subject: Healthcare Efficiency
  topic: keywords
subject: Electronic Health Records
  topic: keywords
subject: Data Security
  topic: keywords
subject: Health Information Technology
  topic: keywords
creator: Dr. Nadia Ali
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 91
ending page: 98
doi: 10.71465/fht122

The Future of Vaccine Development: Leveraging mRNA Technology for Infectious Diseases
type: item
description: The advent of mRNA technology represents a significant leap forward in the field of vaccine development, offering unprecedented speed and flexibility in responding to infectious diseases. This article explores the current state of mRNA vaccine technology, highlighting its applications, advantages, and challenges. By examining recent advancements and case studies, particularly the success of mRNA vaccines in combating COVID-19, the paper elucidates how mRNA technology can revolutionize vaccine development for various infectious diseases. It also addresses the regulatory, manufacturing, and public health implications of mRNA vaccines, providing a comprehensive overview of future prospects and potential hurdles in this innovative field.
subject: Articles
  topic: section
subject: mRNA technology
  topic: keywords
subject: vaccine development
  topic: keywords
subject: infectious diseases
  topic: keywords
subject: COVID-19
  topic: keywords
subject: biotechnology
  topic: keywords
subject: vaccine efficacy
  topic: keywords
subject: public health
  topic: keywords
subject: regulatory challenges
  topic: keywords
subject: mRNA vaccines
  topic: keywords
subject: biomedical innovation
  topic: keywords
creator: Dr. Muhammad Usman Raza
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 83
ending page: 90
doi: 10.71465/fht121

Innovations in Personalized Oncology: Integrating Genomic Data into Cancer Treatment
type: item
description: Personalized oncology represents a transformative approach to cancer treatment, leveraging genomic data to tailor therapies to individual patients. This article reviews recent innovations in the integration of genomic data into cancer care, highlighting advancements in genomics, bioinformatics, and therapeutic strategies. We discuss the impact of genomic profiling on treatment decisions, the development of targeted therapies, and the challenges associated with implementing personalized approaches in clinical practice. By examining case studies and emerging technologies, we provide a comprehensive overview of how genomic data is reshaping the landscape of oncology and improving patient outcomes.
subject: Articles
  topic: section
subject: Personalized Oncology
  topic: keywords
subject: Genomic Data
  topic: keywords
subject: Targeted Therapy
  topic: keywords
subject: Cancer Treatment
  topic: keywords
subject: Bioinformatics
  topic: keywords
subject: Genomic Profiling
  topic: keywords
subject: Precision Medicine
  topic: keywords
subject: Molecular Oncology
  topic: keywords
subject: Therapeutic Strategies
  topic: keywords
subject: Clinical Implementation
  topic: keywords
creator: Dr. Rabia Malik
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 67
ending page: 74
doi: 10.71465/fht120

Analyzing the Effectiveness of Public Health Campaigns in Preventing Non-Communicable Diseases
type: item
description: Public health campaigns play a crucial role in the prevention of non-communicable diseases (NCDs) such as cardiovascular diseases, diabetes, and cancer. This article evaluates the effectiveness of various public health campaigns designed to mitigate the incidence of NCDs. Through a systematic review of recent studies and campaign evaluations, this paper examines key strategies, target populations, and outcomes associated with these campaigns. The analysis highlights successful approaches and identifies factors contributing to the success or failure of these interventions. The findings suggest that multifaceted campaigns incorporating community engagement, digital media, and policy support are most effective in reducing NCD prevalence. Recommendations for future campaigns are provided, emphasizing the need for tailored strategies and continuous evaluation to enhance public health outcomes.
subject: Articles
  topic: section
subject: Public Health Campaigns
  topic: keywords
subject: Non-Communicable Diseases
  topic: keywords
subject: Prevention
  topic: keywords
subject: Cardiovascular Diseases
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Cancer
  topic: keywords
subject: Community Engagement
  topic: keywords
subject: Digital Media
  topic: keywords
subject: Policy Support
  topic: keywords
creator: Dr. Samina Farooq
rights: Copyright (c) 2024 Frontiers in Healthcare Technology https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-12-31
publication date: 2024-12-31
starting page: 75
ending page: 82
doi: 10.71465/fht119

Evaluating the Effectiveness of Mobile Health Apps in Chronic Disease Management
type: item
description: The rise of mobile health (mHealth) applications has introduced new methods for managing chronic diseases. This study aims to evaluate the effectiveness of mHealth apps in chronic disease management by reviewing existing literature, assessing the impact on patient outcomes, and identifying key factors influencing their effectiveness.
subject: Articles
  topic: section
subject: Mobile Health Apps
  topic: keywords
subject: Chronic Disease Management
  topic: keywords
subject: Patient Outcomes
  topic: keywords
subject: Systematic Review
  topic: keywords
subject: mHealth
  topic: keywords
creator: Dr. Faisal Khan
rights: Copyright (c) 2024 Frontiers in Healthcare Technology
date: 2024-06-30
publication date: 2024-06-30
starting page: 58
ending page: 66

Exploring the Role of Big Data in Predicting and Preventing Epidemics
type: item
description: The emergence of big data has revolutionized how healthcare professionals and epidemiologists approach disease surveillance and epidemic prevention. With vast amounts of data generated from various sources such as electronic health records (EHRs), social media, and environmental sensors, it is now possible to identify patterns that indicate the onset of epidemics. This paper explores the potential of big data analytics in predicting and preventing infectious disease outbreaks. By integrating diverse datasets, applying machine learning algorithms, and utilizing real-time data processing, healthcare systems can respond more effectively to public health threats. The paper also discusses the challenges associated with data privacy, algorithmic biases, and the need for robust infrastructure to support these systems. The findings underscore the critical role of big data in enhancing public health preparedness and reducing the impact of future pandemics.
subject: Articles
  topic: section
subject: Big Data
  topic: keywords
subject: Epidemic Prediction
  topic: keywords
subject: Infectious Diseases
  topic: keywords
subject: Data Analytics
  topic: keywords
subject: Machine Learning
  topic: keywords
subject: Disease Surveillance
  topic: keywords
subject: Public Health
  topic: keywords
subject: Epidemic Prevention
  topic: keywords
subject: Healthcare Technology
  topic: keywords
subject: Data Privacy
  topic: keywords
creator: Dr. Imran Javed
rights: Copyright (c) 2024 Frontiers in Healthcare Technology
date: 2024-06-30
publication date: 2024-06-30
starting page: 46
ending page: 57

Integrative Approaches to Pain Management: Combining Conventional and Alternative Therapies
type: item
description: Pain management is a complex field requiring a multidisciplinary approach to address the multifaceted nature of pain. This article explores integrative approaches that combine conventional medical treatments with alternative therapies to provide comprehensive pain relief. We review current research on the efficacy of various integrative methods, including pharmacological treatments, physical therapy, acupuncture, and mindfulness practices. The study highlights the benefits of a holistic approach in improving patient outcomes and quality of life, while also addressing potential challenges and limitations. By examining case studies and clinical trials, this paper offers insights into best practices for combining these modalities to achieve optimal pain management.
subject: Articles
  topic: section
subject: Pain management
  topic: keywords
subject: integrative therapies
  topic: keywords
subject: conventional medicine
  topic: keywords
subject: alternative therapies
  topic: keywords
subject: acupuncture
  topic: keywords
subject: mindfulness
  topic: keywords
subject: physical therapy
  topic: keywords
subject: pharmacological treatment
  topic: keywords
creator: Dr. Sana Farooq
rights: Copyright (c) 2024 Frontiers in Healthcare Technology
date: 2024-06-30
publication date: 2024-06-30
starting page: 36
ending page: 45

Advancements in Minimally Invasive Surgical Techniques: Benefits and Risks
type: item
description: Minimally invasive surgical (MIS) techniques have revolutionized the field of surgery by offering alternatives to traditional open surgeries. This paper reviews recent advancements in MIS, including laparoscopic, endoscopic, and robotic-assisted procedures. We evaluate the benefits such as reduced postoperative pain, shorter recovery times, and minimal scarring. We also address the risks and limitations associated with these techniques, including potential complications, longer learning curves, and high costs. The aim is to provide a comprehensive overview of the current state of MIS and its implications for both patients and healthcare providers.
subject: Articles
  topic: section
subject: Minimally Invasive Surgery
  topic: keywords
subject: Laparoscopic Surgery
  topic: keywords
subject: Endoscopic Surgery
  topic: keywords
subject: Robotic Surgery
  topic: keywords
subject: Surgical Innovations
  topic: keywords
subject: Postoperative Care
  topic: keywords
subject: Surgical Risks
  topic: keywords
subject: Patient Outcomes
  topic: keywords
creator: Dr. Ahmed Ali Khan
rights: Copyright (c) 2024 Frontiers in Healthcare Technology
date: 2024-06-30
publication date: 2024-06-30
starting page: 23
ending page: 35